Peptide Academy · Metabolic

Tesofensine

Also known as Triple monoamine reuptake inhibitor

Educational research summary, not medical advice. Many compounds here are not approved for human use. Talk to a licensed clinician before making any health decision.

The Peptide Academy is free to read. Members also get the research protocols for Tesofensine, dose and vial tracking, and an AI Advisor with cited sources. Try it all free for 7 days, no card needed.

Start my free 7-day trial

What is Tesofensine?

A non-peptide weight-loss compound repurposed from Parkinson's research.

How it works

Inhibits dopamine, noradrenaline and serotonin reuptake, suppressing appetite and increasing energy expenditure.

What it has been studied for

Suppresses appetite
Supports weight loss
May increase energy expenditure

These are effects reported or investigated in research, much of it preclinical. They are not proven outcomes or health claims.

Published research

Phase 2 trial showed ~10% weight loss over 24 weeks

Half-life

N/A — small molecule drug (not a peptide; half-life ~200 hours)

Cautions

Raises heart rate and blood pressure; unapproved.

Side effects & fixes

Common side effects

—Human side-effect data is limited or absent for this compound
—Injection-site redness, itching or soreness is the most commonly reported effect for injected research peptides

Histamine reactions

Possible at the injection site, as with most injected peptides.

Common fixes

Rotate injection sites (abdomen, thighs, upper arms) and stay at least an inch from the last spot.
Let the alcohol swab dry fully, let the solution reach room temperature, and inject slowly with a fresh needle.
A cold compress for 5–10 minutes eases a red or itchy welt; it should fade within a day.
For mild itching, redness or flushing, a non-drowsy over-the-counter antihistamine (such as cetirizine or loratadine) is commonly used — check with a pharmacist first, especially if you take other medicines.
Start low, change one thing at a time, and keep a log of how you feel.

Stop and get help

Any unexpected or severe symptom — stop and contact a doctor.
Stop and get emergency help for swelling of the face, lips, tongue or throat, trouble breathing, widespread hives, chest pain or fainting.

Basis: Limited data; general experience with injected peptides. Educational only, not medical advice.

Medication concerns

Theoretical: no human interaction studies

Antidepressants (SSRIs, SNRIs, MAOIs), triptans, tramadol and stimulants
Tesofensine blocks serotonin, dopamine and norepinephrine reuptake. Combining risks serotonin syndrome, high blood pressure and a racing heart. MAOIs are especially dangerous.
Blood pressure and heart medicines
It raises heart rate and blood pressure.
Everything else you take, including supplements
Bring a full list of medicines and supplements to your pharmacist or clinician before starting.

Basis: No interaction studies; concerns follow from its triple monoamine reuptake mechanism. Educational only, not medical advice. Never stop or change a prescribed medicine without your prescriber.

Protocols & tracking are members-only

Members see the research protocols for Tesofensine, plan schedules, track every dose and vial, and ask the AI Advisor questions with cited sources. Try every Researcher feature free for 7 days, no card needed.

Start my free 7-day trial Reconstitution calculator

More metabolic compounds

Browse all compounds in the Peptide Academy →