Peptide Academy · Metabolic

Cagrilintide

Also known as Amylin analog

Educational research summary, not medical advice. Many compounds here are not approved for human use. Talk to a licensed clinician before making any health decision.

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What is Cagrilintide?

A long-acting amylin analog studied for weight management, often combined with GLP-1 agonists.

How it works

Activates amylin receptors in the area postrema, enhancing satiety and slowing gastric emptying through a pathway distinct from GLP-1.

What it has been studied for

Complementary mechanism to GLP-1 (amylin receptor pathway)
Up to 22.7% weight loss in CagriSema combination (Phase 2)
Reduces food intake via brainstem satiety centers
Slows gastric emptying independently of GLP-1
Once-weekly injection (long half-life)
Additive to semaglutide without significantly increased side effects
May enable lower GLP-1 doses with equivalent or superior results

These are effects reported or investigated in research, much of it preclinical. They are not proven outcomes or health claims.

Published research

Phase 2 data show dose-dependent weight loss as monotherapy
CagriSema (cagrilintide + semaglutide) phase 3 program for obesity

Half-life

~160 hours (~7 days; amylin analog)

Cautions

Investigational. GI side effects common during titration.

Side effects & fixes

Common side effects

—Nausea, especially in the first days after starting or raising the dose
—Diarrhea or constipation
—Reduced appetite, early fullness, burping or reflux
—Fatigue and lightheadedness when eating very little
—Mild redness or itching at the injection site

Histamine reactions

Uncommon. Mild injection-site redness or itching can occur; widespread hives or swelling are rare and need urgent care.

Common fixes

Titrate slowly and stay longer at a dose that causes nausea before moving up.
Eat small, low-fat meals, stop at the first sign of fullness, and avoid lying down for 2–3 hours after eating.
Drink plenty of fluids with electrolytes; dehydration makes nausea and fatigue worse.
For constipation, add fiber gradually with extra water; for nausea, ginger or bland foods help many people.
Prioritise protein at each meal to protect muscle while appetite is low.
Rotate injection sites (abdomen, thighs, upper arms) and stay at least an inch from the last spot.

Stop and get help

Severe, persistent stomach pain (possibly spreading to the back) — this can signal pancreatitis or gallbladder problems.
Vomiting or diarrhea that stops you keeping fluids down.
Stop and get emergency help for swelling of the face, lips, tongue or throat, trouble breathing, widespread hives, chest pain or fainting.

Basis: Prescribing information and clinical trials for the GLP-1 class. Educational only, not medical advice.

Medication concerns

From FDA prescribing information

Insulin and sulfonylureas (glipizide, glyburide, glimepiride)
Higher risk of low blood sugar when combined. Prescribers often lower these doses at the start; check your glucose more often.
Medicines taken by mouth (especially levothyroxine, antibiotics, seizure medicines and warfarin)
Slower stomach emptying can delay or reduce how they're absorbed, most of all after the first dose and each dose increase. Ask your prescriber whether timing or monitoring should change.
Birth control pills
Tirzepatide can make pills less reliable when starting and raising the dose; see Birth control & pregnancy on this card.
Diuretics, ACE inhibitors or ARBs (lisinopril, losartan) and NSAIDs (ibuprofen, naproxen)
Vomiting or diarrhea can dehydrate you and strain the kidneys, a risk these medicines add to. Keep fluids up and call your clinician if you can't keep liquids down.
Planned surgery, sedation or endoscopy
Tell the anesthesia team you take this. Food can stay in the stomach longer, which raises aspiration risk under anesthesia.
Other GLP-1-type medicines (semaglutide, tirzepatide, liraglutide and similar)
Don't stack two drugs from this class; it multiplies side effects without proven benefit.
Everything else you take, including supplements
Bring a full list of medicines and supplements to your pharmacist or clinician before starting.

Basis: FDA prescribing information for GLP-1 medicines (semaglutide, tirzepatide, liraglutide, dulaglutide, exenatide); investigational members of the class are assumed to share these until studied. Educational only, not medical advice. Never stop or change a prescribed medicine without your prescriber.

Protocols & tracking are members-only

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