Peptide Academy · Metabolic

5-Amino-1MQ

Also known as NNMT inhibitor

Educational research summary, not medical advice. Many compounds here are not approved for human use. Talk to a licensed clinician before making any health decision.

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What is 5-Amino-1MQ?

A small-molecule nicotinamide N-methyltransferase inhibitor studied in obesity models.

How it works

Blocks NNMT, preserving NAD+ and SAM pools in adipocytes, which shrinks fat cells and improves metabolic markers in diet-induced obese mice.

What it has been studied for

Inhibits NNMT (fat storage enzyme)
Raises intracellular NAD+ levels
Activates sirtuin anti-aging pathways
Shrinks fat cell size
Promotes fat oxidation within adipocytes
No appetite suppression side effects
Synergistic with NAD+ precursors (NMN/NR)

These are effects reported or investigated in research, much of it preclinical. They are not proven outcomes or health claims.

Published research

Mouse obesity studies show weight loss without reduced food intake
No human trials published

Half-life

~Hours (small molecule; limited human PK data)

Cautions

No human safety data; long-term NNMT inhibition effects unknown.

Side effects & fixes

Common side effects

—Human side-effect data is limited or absent for this compound
—Injection-site redness, itching or soreness is the most commonly reported effect for injected research peptides

Histamine reactions

Possible at the injection site, as with most injected peptides.

Common fixes

Rotate injection sites (abdomen, thighs, upper arms) and stay at least an inch from the last spot.
Let the alcohol swab dry fully, let the solution reach room temperature, and inject slowly with a fresh needle.
A cold compress for 5–10 minutes eases a red or itchy welt; it should fade within a day.
For mild itching, redness or flushing, a non-drowsy over-the-counter antihistamine (such as cetirizine or loratadine) is commonly used — check with a pharmacist first, especially if you take other medicines.
Start low, change one thing at a time, and keep a log of how you feel.

Stop and get help

Any unexpected or severe symptom — stop and contact a doctor.
Stop and get emergency help for swelling of the face, lips, tongue or throat, trouble breathing, widespread hives, chest pain or fainting.

Basis: Limited data; general experience with injected peptides. Educational only, not medical advice.

Medication concerns

Theoretical: no human interaction studies

Diabetes medicines
These metabolic research compounds act on energy and glucose pathways and may lower blood sugar further.
Cholesterol and liver-processed medicines
Not studied together; liver and lipid labs are worth tracking.
Everything else you take, including supplements
Bring a full list of medicines and supplements to your pharmacist or clinician before starting.

Basis: No human interaction studies; concerns follow from AMPK, PPAR or Rev-ERB metabolic mechanisms. Educational only, not medical advice. Never stop or change a prescribed medicine without your prescriber.

Protocols & tracking are members-only

Members see the research protocols for 5-Amino-1MQ, plan schedules, track every dose and vial, and ask the AI Advisor questions with cited sources. Try every Researcher feature free for 7 days, no card needed.

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