Peptide Academy · Sexual Health
Also known as Gonadotropin-releasing hormone
Educational research summary, not medical advice. Many compounds here are not approved for human use. Talk to a licensed clinician before making any health decision.
The Peptide Academy is free to read. Members also get the research protocols for GnRH, dose and vial tracking, and an AI Advisor with cited sources. Try it all free for 7 days, no card needed.
Start my free 7-day trialThe hypothalamic decapeptide that commands the entire reproductive axis.
Pulsatile GnRH-receptor stimulation releases LH and FSH; continuous stimulation desensitizes and suppresses the axis.
Continuous exposure suppresses sex hormones — the opposite of the intended effect.
Common side effects
Histamine reactions
Flushing is common; site itching occasionally.
Common fixes
Stop and get help
Basis: Prescribing information. Educational only, not medical advice.
Medicines that prolong the QT interval (some antiarrhythmics, antipsychotics, ondansetron, macrolide antibiotics)
Long-term hormone suppression can prolong QT; labels advise caution with these.
Diabetes medicines
GnRH agonists can raise blood sugar; glucose is monitored.
Medicines that raise prolactin (risperidone, metoclopramide)
The triptorelin label advises against using them together.
Hormone and fertility lab tests
Results of pituitary and sex hormone tests can be misleading during treatment.
Everything else you take, including supplements
Bring a full list of medicines and supplements to your pharmacist or clinician before starting.
Basis: FDA prescribing information for leuprolide, triptorelin, goserelin and degarelix. Educational only, not medical advice. Never stop or change a prescribed medicine without your prescriber.
Protocols & tracking are members-only
Members see the research protocols for GnRH, plan schedules, track every dose and vial, and ask the AI Advisor questions with cited sources. Try every Researcher feature free for 7 days, no card needed.