Peptide Academy · Cosmetic
Also known as Palmitoyl pentapeptide-4
Educational research summary, not medical advice. Many compounds here are not approved for human use. Talk to a licensed clinician before making any health decision.
The Peptide Academy is free to read. Members also get the research protocols for Matrixyl, dose and vial tracking, and an AI Advisor with cited sources. Try it all free for 7 days, no card needed.
Start my free 7-day trialA topical cosmetic peptide that stimulates collagen production in the skin's extracellular matrix.
The palmitoylated KTTKS fragment mimics collagen-breakdown products, signaling fibroblasts to synthesize new collagen and elastin.
Short — minutes to hours (topical cosmetic peptide)
Cosmetic ingredient; not for injection.
Common side effects
Histamine reactions
Itching or a rash can occur in sensitive skin.
Common fixes
Stop and get help
Basis: Cosmetic-ingredient safety assessments. Educational only, not medical advice.
Prescription retinoids (tretinoin), acids and benzoyl peroxide
Applied on the skin, these peptides have no meaningful medication interactions; layering with strong actives can raise irritation.
Basis: Topical cosmetic peptides with minimal absorption into the body. Educational only, not medical advice. Never stop or change a prescribed medicine without your prescriber.
Protocols & tracking are members-only
Members see the research protocols for Matrixyl, plan schedules, track every dose and vial, and ask the AI Advisor questions with cited sources. Try every Researcher feature free for 7 days, no card needed.